Horizon® DXA System

Powerful Images, Clear Answers

• Bone Mineral Density (BMD) measurement of hip, lumbar spine, forearm, whole body… for an accurate fracture risk assessment including FRAX® calculation.
• High resolution DXA images to assess vertebral fractures and incomplete atypical femur fractures (AFF) for a complete diagnosis.
• Advanced bone health measurements to go beyond current standard of care in bone health.

The Stark Reality of Osteoporosis

• Worldwide, osteoporosis causes more than 8.9 million fractures annually, resulting in an osteoporotic fracture every 3 seconds.⁵
• Prevalence: 8.9 Million fractures Globally.⁵ After 50+, 1 out of 3 women and 1 out 5 men will experience a fragility fracture.⁶ Every 3 seconds a fracture occurs.⁵
• Mortality: 20% of people will die within one year of a hip fracture.⁷
• Cost: $37 billion per year for EU 6 countries with an estimated cost increase of 27% 2017-2030.⁸

Underdiagnosed and Undertreated⁹

• 80% of people who have had at least one osteoporotic fracture are neither identified nor treated for osteoporosis.
• Only 1/3 of vertebral fractures come to clinical attentions.
• People with type 1 diabetes have lower bone mineral density and a higher risk of osteoporotic fractures.
• Only 40% of high risk chronic oral glucocorticoids users have testing or treatment.

Results, including comparison to NAHNES reference data, are available immediately and use colour mapping to identify fat, lean muscle mass and bone.

Advanced Body Composition¹⁰

Individual fat, lean and bone distribution as well as clinical indices are improving the clinical evaluation in certain condition like:

• Obesity (excess of fat mass and its localisation)
• Monitoring fat and lean distribution during weight changes
• Sarcopenia (decrease of muscle mass)
• Bariatric surgery patient monitoring

DXA Complete Diagnostic Tool

Get a wider assessment of elderly health on Osteoporosis, obesity, Sarcopenia

• Osteoporosis assessment with BMD measurements, Vertebral Fracture Assessment (VFA) and fracture risk assessment.
• Obesity: Fat Mass Index, whole body % fat as well as regional % fat for better profiling of obesity (central, abdominal or peripheral).
• InnerCore: Cardiometabolic risk assessment (Visceral Obesity).
• Sarcopenia: Provide lean (muscle) mass assessment.

Sarcopenia

• The risk of disability is 1.5 to 4.6 times higher in older persons with sarcopenia than in older persons with normal muscle.¹²
• In a review of literature, worsening sarcopenia followed trends in losses of muscle strength as well as impairment of daily functioning.¹³ In one study, the prevalence of sarcopenia increased dramatically with age from 4% of men and 3% of women aged 70-75 to 16% of men and 13% of women aged 85 or older.¹⁴
• While there are still no approved treatments for sarcopenia, there are lifestyle changes you can make to help you live with this disease. These include resistance training and a nutritious diet. Appropriate steps should also be taken to avoid falls.
• ALM Index is used to determine the level of muscle mass,¹⁴ < 7.26 kg/m2 for men and < 5.45 kg/m2 for women = significantly increased risk of adverse functional status, such as higher risk of disability, falls and fractures.¹³

Cardio vascular and cardio metabolic risks evaluation:¹¹ Severe wasting accompanying disease states such as cancer, congestive cardiomyopathy and end-stage renal disease.
Sarcopenic Obesity:¹¹ In conditions such as malignancy, rheumatoid arthritis and ageing, lean body mass is lost while fat mass may be preserved or even increased.
Frailty:¹¹ Geriatric syndrome resulting from age-related cumulative declines across multiple physiologic.

Body Composition for Human Performance

Body Composition scans can be useful to athletic programs, physical trainers, and coaches, providing detailed measurements of the body by looking at bone density, lean mass, and fat mass. This information is critical for accurately assessing the state of a patient or athlete’s health and defining successful treatment plans and training programs.

Assessing Injury Prevention & Recovery

The detailed information allows sports programs to review information about each athlete and provide guidance on how best to avoid future or repeat injuries before they happen. It provides the ability to track progress of athletes with previous injuries who have undergone surgeries to understand whether they are losing or retaining muscle during the rehab process. Body composition can also play an important role in assisting symmetrical muscle developments for athletes of all sports. The data provides information on muscle mass and bone density for the entire body, which can be used to alter an athlete’s training program to gain more symmetry and ultimately prevent injury.

Enhancing Nutritional Programs

Body composition can also be used to create personalised nutrition programs for patients and athletes to complement training and weight loss programs. Using the data, a tailored nutritional strategy can be developed to prescribe certain intake of foods that will help patients or athletes meet their goals of weight loss, maintaining muscle, or gaining muscle. The initial scan can be used as a baseline, and performance can be tracked with additional scans throughout the duration of the training or weight loss program. Doctors and athletic trainers can utilise the graphical colour reports to show patients exactly where they are losing fat and gaining more muscle over time.

• Initial assessment of fat mass, lean mass to define weight and distribution (fat/lean balance) targets
• Leverage segmental body composition (arms, legs) and bone assessment
• Monitor training and nutrition program effects over time
• Continuous monitoring: pre/post training – competition time – before and after resting time
• Define optimal weight profile by position/performance
• During rehabilitation track progress and help to define “back to field” time after injury

The Female Athlete Triad is a syndrome of three interrelated conditions that exist on a continuum of severity, including:

• Energy deficiency with or without eating disorder
• Menstrual disturbances/amenorrhea
• Bone loss/osteoporosis

Better Understanding of the Body is Key for Improved Cancer Care

• Cancer treatments have strong impact on patient health conditioning the survivor's rate and their day to day life.
• Quantifying the impact of treatment on bone Health and body Composition will help health care professional's to adapt it during and after this treatment phase.
• DXA will assess the risk of secondary osteoporosis (BMD, VFA) and highlight changes in fat/lean distribution.

Bone Health (Secondary Osteoporosis) and Cancer

• Evaluation of bone loss and fracture risk change with breast cancer treatment - particularly with Aromatase Inhibitors (AI).¹⁵
• Adapted threshold ≤-1.5 T-score + 1RF or ≤ -2 T-score.
• Anastrozole is associated with accelerated bone loss over the 5-year treatment period (6-7%).¹⁶

Evaluation of Body Composition Changes

• Breast cancer and body composition parameters: % fat, fat distribution, central obesity.^17-19
• Body composition, including visceral fat, changes during and after treatment.^20,21

Hologic Breast Health Continuum of Care

• 1 in 11 women will have breast cancer²²
• 1 in 3 women will have osteoporosis²³
• High levels of abdominal fat increases your risk of breast cancer, BMI is not a good indicator²⁴
• Bone loss with breast cancer treatment leading to specific management¹⁶
• Monitor fat and lean mass changes including VAT to prevent cachexia or obesity during treatment²⁵

Children Growth

• Every child has his own development rate influenced by genetics, nutrition, physical activity and so on.
• Many disorders (hormones deficiencies, diseases), chronic diseases and their treatments are affecting bone, adipose and lean tissue metabolism.

Elderly Health

• Between 2010-2050, population 60+ will nearly double (12 to 22%).²⁹
• By 2030, 1 in 6 people in the world will be 60+ year-old.²⁹
• By 2020, the number of people aged 60 years and older will outnumber children younger than 5 years.²⁹
• Simultaneous combined health disorders affecting elderly population, musclo skeletal diseases, CPOD, Diabetes, CVD, vison impairment, and so on.
• "Increase of elderly population puts pressure on current health care systems and patients. Sarcopenia is estimated to increase hospitalization costs by 58.5% for patients aged <65 years and 34% for patients aged ⩾65 years."³⁰
• Early intervention enables healthier and longer living